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I think it was already eluded to here, but after watching the Zimmerman trial, I'm convinced that a prosecutor will use anything they can against you. Some of the simple, everyday facts of concealed carry were used to paint Zimmerman in a negative light such as:

the fact that his gun was semi-automatic
It had no external safety
carrying the gun "topped off" with one in the chamber and a full magazine
The fact that the gun had a 4.3 lb trigger

I'm sure I'm missing something, but those are the ones that I recall sticking out in my mind. Ultimately though, I don't think the caliber will matter much. If you have a DA that's ready to prosecute you on a self-defense case, then he'll paint any caliber out to be bad.