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I agree with others who have commented that agressive prosecutors will use anything they can to skewer the defendant. Pointing out the fact the defendant was carrying some type of "cannon" would be a good point to make to swing a jury picked in part by the prosecutor to be possible gun haters. My personal opinion is something like a .380 or 9mm is perfectly adequate for carry protection. The 9mm round has been dispatching threats satisfactorily for thousands of shooters for over 100 years and it is also more safe to use with others around because it probably stays in the bad guy. The prosecutor would maybe have no case if a person legitimately shot a clear threat but if that round, say a .44 magnum or some other large "hot" round also killed the person behind the BG the story could be different.

IMHO carrying unnecessarily big cal pistols is not necessary and it opens a person for several different problems. While I would not cary a .22 cal for protection the truth is a well placed .22 LR old school lead nose will kill a threat just as dead and instantly as a .45 JHP+P from an 1911 Colt.