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I don't think it matters. However, my practice when cleaning is removing the mag. , eject the chambered round, check the chamber and then disasimble and clean the weapon. I then reasimble the weapon, inset the mag., release the slide to chamber a round ,check to see the weapon is on safe, remove the mag. Insert the round previously in the chamber to top off the mag. And reinsert the mag. Of course the rounds get fired at the range regularly.