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I have a Radical Firearms upper in 300 Blackout. I use it for hog hunting with a suppressor, but I don't shoot subsonic loads.
It was working pretty well for me for a couple of years, but the last two hogs I shot made it into the brush and weren't recovered. I'm hunting at night with a thermal sight. If the hogs get much more than 50 yards into the brush they're hard to find at night, even with a thermal monocular!

Previously I was using an AR-10 shooting .308 bullets and if I lose another hog I'll probably switch back to it.

I rate the 300 BLK as roughly equal to the 7.62X39 (AK-47) round. It's sufficient for hogs but shot placement may be slightly more critical than with a 6.5 Grendel or a 6.8SPC. My shots are typically around 100 yards or less, never over 150 yards. Remember, I'm not shooting subsonic loads.

My original intention was to use subsonic rounds when shooting at a feeder (generally 60-70 yards max range) but even there I've concluded that it's too underpowered.

Your Mileage May Vary. I'm just an average marksman. Someone who shoots better will obviously get better results.
But if the next hog I shoot runs off, the AR-10 is coming back out …

Back to the original question — I have had no problems with the Radical Firearms upper in 300 BLK.