In regards to the Glock compact .45's, my understanding is that you have it backwards. The double-stack model 30 is generally considered to be completely reliable by all accounts I have heard, while the single-stack model 36 has been somewhat problematic for
some owners. Glock knows how to make ugly and, for many, uncomfortable double-stack pistols that just plain work, but the model 36 was their first release (I won't venture to say it was their first attempt) of a single-stack design. It would follow that the new design would be more problematic. All that being said, there are many very happy owners of both models. If the model 30 is a bit too large for your wife's hands, Glock has released the 30SF, which has a little bit less girth in the grip. I don't own any of these models of Glock pistols, so take what I have written with a grain of salt, but my wife and I are very happy with our model 19 and 23, respectively.
You might want to look at the model 23 or 27, if your wife likes the Glock line and is considering the .40SW cartridge. It is noticeably smaller in the grip that the model 30. It is a somewhat snappy cartridge, but the 23 handles it nicely, IMHO. The 27 has an excellent reputation for doing the same and having Glock's usual reliability. Also, the 27 will take the larger 23 and 22 mags (I would recommend them as backup or secondary mags for concealability purposes); the 23 will take the larger model 22 mags; and the model 30 will take the larger model 21 mags, in case capacity is a concern of yours and/or your wife's.
I'm not knocking any of the other suggestions already given, but you mentioned the Glocks in the OP. Actually, if I were going to buy a large capacity .45, I would get the XD .45, because it just plain fits my hand better than the Glock .45's. I also have a 5" 1911 that I'm breaking in, so I can move it into my carry rotation. What can I say, I love all sorts of guns (I just hate my budget

). The most important thing is to let your wife pick what fits her best within reason.
Remember, in a life-or-death situation, when seconds count, the police are only minutes away.
Barre